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[1] The cyclic disulfide structure is thought to contribute to conformational rigidity and resistance to peptide degradation in biological environments. Pharmacokinetic studies in murine plasma indicated a plasma half-life of approximately 4 minutes under in vitro conditions, reflecting rapid enzymatic metabolism of the peptide backbone
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On examination, she was afebrile, conscious, alert and oriented, noted to have pallor, bipedal oedema, hyperpigmentation over the tongue, bilateral hands and feet (Fig

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