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A recent study has indicated that overdose (intraperitoneal dose of 800 mg/kg body weight) of NAC causes organ dysfunction, fatty liver, renal tubular necrosis, splenic damage, and even death in mice (Tsai et al., 2024)
Although the study did not meet the expected goals, the addition of bevacizumab to chemotherapy increased the mPFS and ORR of the first-line treatment of GC, and also showed geographical differences, with the greatest survival benefit in American patients and almost no survival benefit in Asian patients
Petruzzelli, R., Christensen, D
Neurotrophic factors in neurodegeneration
