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The reference point is Lipinskis Rule of 5, an empirical framework from 1997 thats become one of the most cited ideas in drug research

45 Interestingly, while UBE1 expression remains unchanged in human heart failure, experimental studies have shown that overexpression of UBE1 or UBE6 in neonatal rat ventricular cardiomyocytes (NRVCMs) increases the ubiquitination of Nav1.5, a major transmembrane protein essential for cardiomyocyte depolarization

doi: 10.1016/j.biopha.2024.116376

D., Wu A
