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So, for example, if you made a change and then something improved, look at everything that changed and were they all overlapping, in which case it's kind of hard to figure out what it is, or is there a distinct association, time-wise, between something changing and something improving
Cirelli C (2002) Invited review: how sleep deprivation affects gene expression in the brain: a review of recent findings

Cysteine oxPTMs can lead to both loss 8 and gain of enzymatic functions 9 , and correspondingly rewire cancer metabolism 10,11