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oral administration of FA (500 g/day) was continued from 7 days before the first dose of pemetrexed until 21 days after the last dose of pemetrexed, whereas 1000 g B12 was administered intramuscularly, 1 week before the first dose of pemetrexed and every three cycles thereafter

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However, older adults may have a more challenging time absorbing B12 from their diet, so it may be necessary to supplement this vitamin

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