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Patients commonly experience neurocognitive deficits such as reduced working memory, slower processing speed and impaired executive function, together with affective symptoms including depression, apathy and anxiety, which heighten the overall neuropsychiatric burden (69, 70)

NAD+ therapy raises intracellular NAD+ concentration to support mitochondrial ATP synthesis and sirtuin enzyme activity

10.1016/j.jprot.2018.04.012 27 ClarkS

Collectively, our findings underscore the pivotal role of S h / T g E in modulating drug particle size within CSD matrices through distinct mechanisms