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Timing isnt just about convenience
Evidence in one sentence: Both delivery systems are biologically plausible and supported by limited human biomarker or pharmacokinetic data, but neither has been proven superior for meaningful clinical outcomes
Gilroy et al
[PUBMED Abstract] Waber DP, Turek J, Catania L, et al.: Neuropsychological outcomes from a randomized trial of triple intrathecal chemotherapy compared with 18 Gy cranial radiation as CNS treatment in acute lymphoblastic leukemia: findings from Dana-Farber Cancer Institute ALL Consortium Protocol 95-01
