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The criteria for exclusion were as follows: rats with signs of external ear disorders (impacted earwax, tumors, external acoustic meatus edema, and hyperemia), rats with middle ear disorders (opacification, hyperemia, and bulging or perforations of the tympanic membrane), and rats without DPOAE in any of the studied frequencies (18 kHz)
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In concentrations previously shown to affect cell development, chlorpyrifos reduced AP-1, but not Sp1 DNA-binding activity

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