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doi: 10.15252/emmm.201910668 107 TurcuAFRegeJAuchusRJRaineyWE

Despite these findings, the study leaves some questions unanswered

Advancements in single-cell RNA sequencing have characterized previously unrecognized spatial heterogeneity and immune functions of stromal cells in the lymph nodes (114, 122, 123, 125, 130, 131), suggesting that the disintegration of the highly organized stromal cell structure will impair the anti-cancer immune responses (132)

While most studies including those in children attempted treatment withdrawal in patients having sustained biochemical remission (normalization of transaminases for more than 2 years)