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doi: 10.1001/jama.2013.281115
[DOI] [PubMed] [Google Scholar] 70.Kim JY, Lee JM, Han JK, Kim SH, Lee JY, Choi JY, et al
Strengths and Limitations of RCTs RCTs are often considered the gold standard for evaluating causal hypotheses, but it is important to clarify what they doand do notdemonstrate
Some of them are drug side effects, contraindications to the use of selected drugs in kidney disease or heart failure, the risk of hypoglycemia, the inability to target every pathophysiological defect associated with hyperglycemia, and the common association of intensive glycemic control with the risk of weight gain
