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Researchers generally refer to oxidative stress when one or more parameters reflecting the balance of free radical processes are disturbed, leading to an increase in the steady-state level of ROS that affects many vital processes

1 Introduction Diabetes mellitus (DM) is a group of endocrine and metabolic disorders characterized by hyperglycemia, and its incidence has been steadily increasing ( Figure 1 )

Critically, to bridge the gap to real-world effects, the system would also incorporate a dynamic tier for in vivo evidence, distinguishing between effects validated in animal models versus human trials and noting known bioavailability limitations