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What the clinical trial evidence shows Mounjaro (tirzepatide) ~22.5% average body weight lost at 72 weeks ( SURMOUNT-1, 15mg) Wegovy (semaglutide) ~14.9% average body weight lost at 68 weeks ( STEP-1 , 2.4mg) Saxenda / Nevolat (liraglutide) ~5-8% average body weight lost at 56 weeks ( SCALE trial ) For context, prior to GLP-1 medications, the most effective non-surgical weight loss intervention available was a combination of intensive lifestyle modification and Orlistat , which typically produces 5 to 8% weight loss

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The reason why may have less to do with its function as a sleep inducer, and more to do with some research suggesting marginal (but noticeable) improvements in cognitive function in the day following (4)

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