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Description
Despite promising preclinical data, clinical trials for FK866 yielded no objective responses but still induced dose-limiting thrombocytopenia 173
It cleaves disulfide bonds in mucus, thereby limiting crosslinking and successfully decreasing mucosal viscosity 199,200
Biochem Biophys Res Commun 544:4451 Xiong Q, Li X, Li W, Chen G, Xiao H, Li P, Wu C (2021) Wdr45 mutation impairs the autophagic degradation of transferrin receptor and promotes ferroptosis
Univariate analysis showed no significant changes in calcium levels over time or interactions between treatments
