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Experimental studies in Wistar rats treated with PZA or PA showed hepatotoxicity, as demonstrated by elevated serum alanine aminotransferase, aspartate transaminase, and galactose single-point levels (Tostmann et al., 2008

MERRF affects multiple systems and typically presents with myoclonus as the initial symptom, followed by generalized seizures, ataxia, fatigue, motor intolerance, and dementia

[DOI] [PubMed] [Google Scholar] 206.Ramadass S.K., Anantharaman N.V., Subramanian S., Sivasubramanian S., Madhan B

doi: 10.1093/brain/awad331 68 YoonJHSeoYJoYSLeeSChoECazenave-GassiotAet al