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Figure 15: Gouty Destruction at Multiple Finger Joints

Type 2 diabetes mellitus: New pathogenetic mechanisms, treatment, and the most important complications

This results in increased expression of hypoxia-inducible factors (HIFs), which promote angiogenesis (via VEGF upregulation) and invasion ( 4.3.3 Acidosis Tumor acidosis crucially impacts the effectiveness of various therapeutic interventions by modulating the TME and promoting oncogenesis

M., DeLuca, J