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In more advanced cases, injectable options may be necessary

This tetrapyrrole-derived ring is unusual in that it has undergone a ring-contraction process meaning that one of the bridging ( meso ) carbon atoms that are used to connect the four pyrrole rings has been eliminated, thereby generating a macrocycle that is both contracted and lop-sided in comparison to the tetrapyrrole-frameworks that are associated with heme and chlorophylls [10]

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TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice