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Activation of the -adrenergic signaling pathway by catecholamines, including NE from the SNS and also adrenal-derived NE and EPI, is the most robust physiological mechanism underlying the stimulation of lipolysis in peripheral adipocytes (463)

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Cardiac Manifestation in Heterozygotes Heterozygous carriers usually have about 50% carnitine transport activity in fibroblasts and can have borderline low plasma carnitine levels due to increased urinary loss

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