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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

A5: Yes, B12 injections are typically very safe if administered by skilled medical experts

Medical history The doctor will also take a detailed medical history, including questions about dietary habits, family history of anemia, and any medications being taken

However, there are some groups of people that may be at a greater risk of vitamin B12 overdose