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Clinical data demonstrates that gastrointestinal side effects follow a predictable pattern of being most prominent during treatment initiation and dose escalation periods, then declining substantially as the body adapts

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121 The concept of cognitive reserve also becomes particularly relevant during midlife, when its longterm implications are more apparent

Fluorescence was analyzed using a flow cytometer (BD FACSCanto II, BD Biosciences, Franklin Lakes, NJ, USA) equipped with a 488 nm laser for excitation