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Enzalutamide, an androgen receptor antagonist, enhances myeloid cell-mediated immune suppression and tumor progression

The molecule was developed by Frank Ng's group at Monash University and Metabolic Pharmaceuticals in Australia during the 1990s and 2000s as a potential anti-obesity drug intended to isolate the lipolytic region of hGH without activating the growth hormone receptor or raising IGF-1.nnIn published preclinical work, the fragment has been shown to stimulate lipolysis, suppress lipogenesis, and modulate the beta-3 adrenergic receptor pathway in adipose tissue rather than acting through the classical hGH receptor

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It is a known inducer of genes encoding phase II defense and antioxidant enzymes including GPx, GST, and GLCL [196, 211]