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CYP27B1 =cytochrome P450 family 27 subfamily B member 1

doi: 10.1096/fj.13-231381 100 ClementSRefetoffSRobayeBDumontJESchurmansS

In industrialized countries, the majority of the population has adequate iron stores, usually totaling approximately 45 g (representing approximately 38 and 50 mg iron/kg body weight for adult women and men, respectively)

Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (83)