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This includes in vitro, ex vivo and in vivo animal studies

3.3.4 Mitochondrial dysfunction under high-glucose conditions exacerbates ferroptosis Mitochondria are major ROS sources in ferroptosis

Because we suspected that glucagon-stimulated changes in liver cAMP production may only be detectable after acute receptor activation, we next tested the acute and chronic effects of exogenous glucagon receptor agonism on liver cAMP content in wildtype male C57BL/6 J mice

This matters enormously
