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It mostly results from a mutation, rather than a deletion, of the Nf1 gene
C max was analysed using the same approach, whereas t max and all exploratory pharmacokinetic endpoints were summarised by renal function group using descriptive statistics
We have previously shown that the cell death associated with lysosomotropic compounds can be rescued by Bafilomycin A, which increases lysosomal pH and prevents compound accumulation, further supporting lysosomal accumulation as the cause for cell death [54]
[DOI] [PMC free article] [PubMed] [Google Scholar] 326.Wang H., Zuo D., Zhu B., Du X., Gu L
