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Description
Micro: The Foundation Stone of the Biosphere

MLOs have gained prominence recently because of their ability to concentrate specific proteins, nucleic acids, and small molecules in specific subcellular locations without the need for a lipid membrane

In patients with FCMD, selective deficiency of -dystroglycan as well as a secondary deficiency in laminin-211/merosin, which is specifically expressed in skeletal muscle, Schwann cells and thymocytes 9 , results in the disruption of a series of connections between the basement membrane and the cytoskeleton maintained via -dystroglycan, leading to the development of muscular dystrophy

Although there is a wide range of data available on the toxic effects of MGO on different compartments of the BBB, a detailed description of the effect of MGO on the BBB is missing to date
