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There may be a threshold at which the neuroprotective functions of reactive astrocytes shift toward neurotoxic effects, acting as adversaries of neurons
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Thus, a vicious cycle is established in which aging, while imposing neurological changes intrinsic to advanced age and increasing susceptibility to circadian disturbances, also contributes to the worsening of chronodisruption by impairing the SCNs ability to synchronize with environmental stimuli
