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SIRT1 can bind and retain GAPDH in the cytosol, but SIRT5 actives GAPDH via demalonylation, thereby elevating glycolytic flux

While it is naturally produced by the human liver, levels often deplete due to age, pollution, and the modern Malaysian lifestyle

The FOXO4p53 axis in senescence p53 is a major tumour suppressor and master regulator of cellular stress responses: DNA damage, oxidative stress, oncogene activation

Consequently, the most realistic therapeutic applications of fluopsin C lie in localized or formulation-controlled contexts, including topical therapies, anti-biofilm adjunctive treatments, and encapsulated delivery systems designed to expand its therapeutic window
