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the honest limits (correlation not causation, the contested spoon, the WHO caveat)

The hypothesis that these reactive intermediates are responsible for cell death is supported by the observation that a cell line selected for erastin resistance showed several-hundred-fold upregulation of AKR1C family genes (Dixon et al., 2014), which encode aldoketoreductases that, among other functions, reduce reactive end-products of lipid peroxidation to unreactive compounds (MacLeod et al., 2009)

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Conclusion Pernicious anemia is a manageable condition with timely diagnosis and appropriate treatment