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In March 2022, Tsvetkov et al.s research demonstrated that excessive intracellular copper induces the aggregation of dihydrolipoyllysine-residue acetyltransferase (DLAT), which is associated with the mitochondrial tricarboxylic acid (TCA) cycle, and is related to mitochondrial activity, resulting in a novel form of copper poisoning-induced cell death

This immunomodulatory effect may contribute to their broader anti-inflammatory actions [71]

As a result, GGT serves not only as a marker of oxidative stress but also as a critical component of the antioxidant defense system, making it particularly valuable in the context of NAFLD

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