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Subject terms: Biochemistry, Cell biology, Metabolic disorders Introduction Nicotinamide adenine dinucleotide (NAD + ) is an essential redox coenzyme that exists between the oxidized form NAD + and its reduced form (NADH) 1

Urine bilirubin measures the presence of bilirubin, a yellow pigment produced from the breakdown of red blood cells, in the urine

The EAT protocol includes, amongst others, the use of hamster-derived S9-fraction for preparation of S9-mix, as it contains higher levels of certain CYPs relevant for metabolic activation of NAs, compared to the standard rat S9-fraction
