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[DOI] [PubMed] [Google Scholar] 87.Bahari H., Rezaiian F., Goudarzi K., Nooshan Mirmohammadali S., Asbaghi O., Sadat Hosseini kolbadi K., Naderian M., Hosseini A

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Synaptic copper Although copper is mainly thought of as a cofactor or allosteric modulator of enzymes with its actions primarily taking place within the intracellular environment (Ge et al., 2022), there is a scattering of evidence that suggest that copper is released from presynaptic neurons and that concentrations within the synaptic cleft can rise to micromolar levels, allowing this metal to act directly, or indirectly via redox reactions, on synaptic receptors