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The reporter was repressed with wild-type WAGO-1 (Fig

Specifically, hyperosmolarity induced by D-mannitol supplementation induced increases in intracellular Ca 2+ that could be suppressed by 1 mmol/l L-carnitine (Fig

The transport system consists of three main proteins, the first of which is the enzyme carnitine palmitoyltransferase I (CPTI) present in the mitochondrial outer membrane that complexes with a long-chain acyl-CoA synthetase and the voltage-dependent anion channel, while the second transport component is carnitine:acylcarnitine translocase (CACT), an integral inner membrane protein, which complexes with carnitine palmitoyltransferase II (CPTII) located on the matrix side of the inner membrane

Sixty 2dayold adults were analysed for each genotype in total, from three independent experiments