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It should be noted that microglia exhibit two primary phenotypes in inflammatory regulation: the M1 phenotype exacerbates tissue damage through pro-inflammatory effects, while the M2 phenotype alleviates neuroinflammation by secreting anti-inflammatory mediators (Hacioglu 2024)

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This review focuses on the analysis of the problem of vitamin B12 hypersensitivity and presents different protocols for cyanocobalamin desensitization based on available literature data

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