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doi: 10.1515/CCLM.2009.247

TMAO has also been shown to induce inflammatory markers in mice and in human aortic endothelial cells and vascular smooth muscle cells owing to activation of MAPK, extracellular signal kinase, and NF-B signaling cascade, along with promoting the recruitment of activated leukocytes to endothelial cells

Human evidence is extremely limited, consisting of three small pilot studies lacking rigorous controls
