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Allergic Reactions and Anaphylaxis In rare cases, more severe allergic reactions can occur

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Adding a second compound while still experiencing significant adverse effects from the first makes it impossible to isolate which agent is responsible for new or worsening symptoms

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Lancet HIV (2019) 3

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In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression

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