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These proteins are crucial for cell-to-cell and cell-to-matrix interactions, playing important roles in tissue integrity and wound healing

In wound infections, TLR signaling is activated by PAMPs such as lipopolysaccharides (TLR4 ligands), lipoteichoic acid (TLR2 ligands), flagellin (TLR5 ligand), and unmethylated CpG DNA (TLR9 ligand) derived from invading bacteria, fungi, or viruses [32]