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In the clinic, he described several months of waxing and waning nodular lesions on the left upper extremity with intermittent spontaneous drainage (Fig

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To signal, FGFs are released from the extracellular matrix by heparinases, proteases or specific FGF binding proteins, and the liberated FGFs subsequently bind to cell surface heparan sulphate proteoglycans (HPSGs) stabilizing the FGF-FGFR interaction [135]

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