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The oxidation of the formed PE-AA may follow either enzymatically through the action of Lox, or non-enzymatically through autoxidation to form PE-AA-OOH, both of which ultimately causes cell death
For example, rats treated with the benzodiazepine antagonist flumazenil along with a benzodiazepine do not develop tolerance but still apparently experience an anxiolytic effect

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[DOI] [Google Scholar] 151.De Saeger J., van Praet S., Vereecke D., Park J., Jacques S., Han T., Depuydt S
