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These samples were collected from women with expected delivery dates ranging from April 1 st , 1991 to December 31 st , 1992 ( 2 ), in southwestern England received approximately 17,000 kg of ATZ annually ( in-utero ATZ exposure may increase the risk of female offspring developing breast cancer later in life ( in-utero estrogenic effects caused by maternal ATZ exposure (see later sections on how ATZ may increase estradiol biosynthesis via CYP19A1 induction to augment estrogen availability and intensify estrogenic effects in the developing fetus)