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2000 May;71(5):559-66

Timolol has a delayed effect on miosis (from 4 to 8 h post-treatment), as well as in normal eyes [151,152]

Weakening of the endogenous antioxidant system leads to uncontrolled ROS production that outweighs the antioxidant capacity of the brain, causing developmental neurotoxicity

Lacreta FP, Brennan JM, Nash SL, Comis RL, Tew KD, ODwyer PJ