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barrier, making the brain accessible to only a few percent of potential drugs intended for treatment inside the central nervous system
For readers interested in learning more about lasso peptides, we encourage starting with excellent papers authored by the research groups led by Mitchell, Marahiel, and Swanson
Chem Res Toxicol 2009;22:699707 [DOI] [PMC free article] [PubMed] [Google Scholar] 30.Tanaka R, Ishima Y, Maeda H, Kodama A, Nagao S, Watanabe H, Chuang VT, Otagiri M, Maruyama T.Albumin fusion prolongs the antioxidant and anti-inflammatory activities of thioredoxin in mice with acetaminophen-induced hepatitis
System xc serves as an amino acid reverse transporter that orchestrates the exchange of extracellular cystine and intracellular glutamate across the cell membrane [77]
