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Description
Dosages used in rodent studies range from 10mg/kg/day to 150mg/kg/day [1, 6, 11]
The whole blood culture model was used to test whether vitamin B12 can regulate, via methyl-dependent epigenetic mechanisms, the expression of inflammatory genes in the leukocytes of patients with moderate and severe forms of the disease and who are already being treated with glucocorticoids
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This difference was achieved without any change in food intake, suggesting the weight loss came from metabolic changes rather than appetite suppression
