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Introduction Mitral valve prolapse (MVP) is the most common form of valve disease, occurring in 23% of the general population, and up to 56% when prodromal or minimal forms are included ( The identification of rare genetic variants with a strong effect or common variants with a weak effect promoting the development of MVP allow us to approach the underlying pathophysiological mechanisms associated with this condition
The chemokine receptor CCR9 acts as a trafficking or homing molecule that selectively causes T cells to move to the small intestine, where they promote persistent inflammation
Han J, et al
