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Chen Y, Yi X, Huo B, He Y, Guo X, Zhang Z

These predicting factors of MTX intolerance included age as continuous variable ( p = 0.089), female sex ( p = 0.022), MTX dose above 17.5 mg/ week ( p = 0.126), use of non-steroidal anti-inflammatory drugs ( p = 0.203), proton-pump inhibitors ( p = 0.164), use of corticosteroids ( p = 0.054), and antiemetics ( p = 0.217)

FoxO-1) that are responsible for the breakdown (or catabolism) of proteins

Eaton JK, Ruberto RA, Kramm A, Viswanathan VS, Schreiber SL
