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Among the metabolic pathways implicated, Kla has garnered attention as a crucial regulator of chemoresistance, particularly in tumors exhibiting high glycolysis and lactate production

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In mice, Tbx3 , a related T-Box binding transcription factor, plays a crucial role in cell-fate determination and liver organogenesis 51 and TBX3 -deficient hPSCs demonstrate reduced hepatocyte differentiation and an increased pancreatic progenitor differentiation 55