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These methods have been extensively applied to efforts in the minimization of bioactivation for lead compounds at the drug discovery stage [711]
2021, Zhang, C., Xie, Y., Chen, H., Lv, L., Yao, J., Zhang, M., Xia, K., Feng, X., Li, Y., Liang, X., Sun, X., Deng, C., & Liu, G
however, the resulting peptide exhibited poor solubility in volatile solvents, complicating their removal by rotary evaporation after the cyclization step
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