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Furthermore, using a redox-inactive knock-in mutant of Atg4a, a major effector of autophagy, we show that the lifespan extension in response to catalase requires a key redox-regulatory cysteine residue, Cys102 in Drosophila Atg4a
, MoralesGonzlez ., MadrigalSantilln E
Accumulation of selective ceramides species might target and disrupt mitochondria function leading to neurodegeneration (Lima et al., 2023)
