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For example, the endoplasmic reticulum (ER) has a relatively oxidizing environment, which is required for structural disulfide formation of membrane and secretory proteins

doi:10.1053/sonc.2002.35524 Giacomini PG, Napolitano B, Alessandrini M, Di Girolamo S, Magrini A

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Here we defined a signature of 59 genes and two metabolites (GSH and NADP) that is robustly associated with NRF2 dependency across an extensive panel of cancer cell lines