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The globally fitted model correctly captured the more substantial contribution of the RSK to SOS negative feedback strength compared to the positive feedback from ERK to Raf, which resulted in the upregulation of pMEK after inhibition of MEK (Fig
doi: 10.1097/WNF.0000000000000314
Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by joint inflammation, largely mediated by pro-inflammatory cytokines
De Bernardis et al., 2018)
