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10.1016/j.bbamem.2018.06.014 66 LaporteA.LortzS.SchaalC.LenzenS.ElsnerM
23 Some of the proteins released from mitochondria into the cytoplasm include apoptosis-inducing factor and endonuclease G, both of which have nuclear localization signals and thus translocate to the nucleus, where the endonuclease cleaves DNA, resulting in DNA fragmentation
Elevated serum cholesterol, liver damage, systemic inflammation, and hypoxic conditions can increase XO secretion via hepatic and other visceral pathways into the bloodstream and bind to the endothelial cell surface, initiating the overproduction of superoxide [77]
& Hasty, A
