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In animal models, tribulus affected a significant reduction in tumor incidence, tumor burden, and cumulative number of papillomas (19) , and relieved cisplatin-induced renal toxicity (41)

HYGIENE A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS A61P33/00Antiparasitic agents AHUMAN NECESSITIES A61MEDICAL OR VETERINARY SCIENCE

In addition to KEAP1, other forms of regulatory proteins of NRF-2 have recently been discovered, such as the E3-Ubiquitin-ligase adaptor, and the -transducin repeats-containing protein (-TrCP), which can also be degraded by Glycogen Synthase Kinase 3 (GSK-3), phosphorylizing NRF-2 into its residue as serine in the Neh 6 domain, corresponding to the recognition of -TrCP [18] (Fig

[26] that both cysteine and methionine contribute approximately equally to GSH synthesis in the liver